ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:37 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: loss_cnaPANCAN227, loss_cnaPANCAN228


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN227, loss_cnaPANCAN228 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 32


Statistically significant associations identified = 9

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a84	loss_cnaPANCAN227, loss_cnaPANCAN228	208	1	1	SB-715992	KIF11	30	892	-2.06	-1.83	-0.13	1.7	0.97 .	0.96 .	1.2 *	5.19e-06	9.45e-34	1.86e-02	1
a215	loss_cnaPANCAN227, loss_cnaPANCAN228	1175	1	1	AG-014699	PARP1, PARP2	31	887	1.61	3.4	4.15	0.758	0.77 .	0.77 .	0.98 .	1.03e-04	8.12e-15	1.23e-01	7.9
a224	loss_cnaPANCAN227, loss_cnaPANCAN228	1239	1	1	YK 4-279	RNA helicase A	24	768	2.3	1.52	2.53	1	0.79 .	0.79 .	0.82 .	1.17e-04	1.27e-08	4.43e-02	8.6
a277	loss_cnaPANCAN227, loss_cnaPANCAN228	1050	1	1	ZM-447439	AURKB	21	775	1.386, 0.693	2.19	3.41	1.22	0.97 .	0.97 .	1 *	1.94e-04	2.91e-12	2.75e-02	12
a310	loss_cnaPANCAN227, loss_cnaPANCAN228	201	1	1	Epothilone B	Microtubules	27	845	-3.44	-4.95	-3.6	1.35	0.73 .	0.73 .	0.65 .	2.72e-04	2.79e-07	1.24e-01	14
a343	loss_cnaPANCAN227, loss_cnaPANCAN228	298	1	1	OSI-930	KIT, VEGFR, PDGFR	29	891	2.33	3.99	4.74	0.752	0.71 .	0.71 .	0.85 .	3.35e-04	2.31e-58	2.78e-01	16
a401	loss_cnaPANCAN227, loss_cnaPANCAN228	1039	1	1	SL 0101-1	RSK, AURKB, PIM3	23	808	2.3	4.48	5.17	0.688	0.93 .	0.92 .	1.1 *	4.66e-04	1.81e-11	1.83e-01	19
a452	loss_cnaPANCAN227, loss_cnaPANCAN228	330	1	1	XMD13-2	RIPK	29	891	2.33	3.33	4.42	1.09	0.82 .	0.82 .	0.97 .	5.81e-04	6.65e-57	7.48e-01	21
a502	loss_cnaPANCAN227, loss_cnaPANCAN228	179	1	1	5-Fluorouracil	DNA antimetabolite	30	883	3.47	3.52	4.8	1.29	0.73 .	0.72 .	1 *	7.28e-04	2.75e-45	2.32e-01	24

All-tests volcano plot